Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells

S Joshi, N Balasubramanian, G Vasam… - European journal of …, 2016 - Elsevier
Angiotensin-converting enzymes, ACE and ACE2, are key members of renin angiotensin
system. Activation of ACE2/Ang-(1-7) pathway enhances cardiovascular protective functions …

ACE2/Ang-(1–7)/Mas axis stimulates vascular repair-relevant functions of CD34+ cells

N Singh, S Joshi, L Guo, MB Baker… - American Journal …, 2015 - journals.physiology.org
CD34+ stem/progenitor cells have been identified as a promising cell population for the
autologous cell-based therapies in patients with cardiovascular disease. The counter …

Targeting angiotensin-converting enzyme-2/angiotensin-(1-7)/Mas receptor axis in the vascular progenitor cells for cardiovascular diseases

YPR Jarajapu - Molecular Pharmacology, 2021 - ASPET
Bone marrow–derived hematopoietic stem/progenitor cells are vasculogenic and play an
important role in endothelial health and vascular homeostasis by participating in postnatal …

Angiotensin-Converting Enzyme 2 Deficiency in Whole Body or Bone Marrow–Derived Cells Increases Atherosclerosis in Low-Density Lipoprotein Receptor−/− Mice

SE Thatcher, X Zhang, DA Howatt, H Lu… - … , and vascular biology, 2011 - Am Heart Assoc
Objective—The renin-angiotensin system contributes to atherosclerotic lesion formation.
Angiotensin-converting enzyme 2 (ACE2) catabolizes angiotensin II (Ang II) to angiotensin 1 …

[HTML][HTML] Angiotensin-(1-7)/angiotensin-converting enzyme 2/mas receptor axis and related mechanisms

AJ Ferreira, RAS Santos… - International Journal of …, 2012 - ncbi.nlm.nih.gov
Cardiovascular disease is America's leading health problem and the leading cause of death.
One person in three suffers from some form of cardiovascular disease. There is an urgent …

Angiotensin-converting enzyme 2 priming enhances the function of endothelial progenitor cells and their therapeutic efficacy

J Chen, X Xiao, S Chen, C Zhang, J Chen, D Yi… - …, 2013 - Am Heart Assoc
Angiotensin-converting enzyme 2 (ACE2) is a lately discovered enzyme catalyzing
Angiotensin II into Angiotensin 1-7. Angiotensin II has been reported to impair endothelial …

A novel angiotensin analog with subnanomolar affinity for angiotensin-converting enzyme

LT Krebs, JM Hanesworth, MF Sardinia… - … of Pharmacology and …, 2000 - ASPET
This study demonstrates that a novel angiotensin I analog, angiotensinogen 3–11 (Lys11),
possesses a high affinity for angiotensin-converting enzyme (ACE), which is substantially …

Beneficial effects of angiotensin-(1–7) on CD34+ cells from patients with heart failure

CT Cole-Jeffrey, CJ Pepine, MJ Katovich… - Journal of …, 2018 - journals.lww.com
The dysfunctional nature of CD34+ cells from patients with heart failure (HF) may make them
unsuitable for autologous stem-cell therapy. In view of evidence that the vasoprotective axis …

Measurement of angiotensin converting enzyme 2 activity in biological fluid (ACE2)

F Xiao, KD Burns - Hypertension: Methods and Protocols, 2017 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2) is a recently described member of the
renin-angiotensin system that hydrolyzes angiotensin (Ang) II to Ang-(1-7), and may thereby …

Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases

N Parajuli, T Ramprasath, VB Patel… - Canadian Journal of …, 2014 - cdnsciencepub.com
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that metabolizes
several vasoactive peptides, including angiotensin II (Ang-II; a vasoconstrictive/proliferative …