The fibroblast growth factor (FGF) signalling pathway has been the focus of intense genetic
and functional research for several decades. The emerging data implicate FGF signalling in …

Fibroblast growth factor receptors comprise a family of four evolutionarily conserved
transmembrane proteins (FGFR1, FGFR2, FGFR3 and FGFR4) known to be critical for the …

Fibroblast growth factor receptors (FGFRs) exist as a gene family of 4 membrane bound
receptor tyrosine kinases (FGFR1-4) that mediate signals of at least 22 fibroblast growth …

The Fgf signalling pathway is highly conserved in evolution and plays crucial roles in
development. In the craniofacial region, it is involved in almost all structure development …

Fibroblast growth factors (FGF) and their receptors serve many functions in both the
developing and adult organism. Humans contain 18 FGF ligands and four FGF receptors …

Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many
craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated …

The first experimental mouse model for FGF2 in bone dysplasia was made serendipitously
by overexpression of FGF from a constitutive promoter. The results were not widely …

Fibroblast growth factors (FGF) play a critical role in bone growth and development affecting
both chondrogenesis and osteogenesis. During the process of intramembranous …

FGFs are key developmental regulators that engage a signal transduction cascade through
receptor tyrosine kinases, prominently engaging ERK1/2 but also other pathways. However …

BACKGROUND: The role of fibroblast growth factor and receptor (FGF/FGFR) signaling in
bone development is well studied, partly because mutations in FGFRs cause human …