A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

C Giannakou, MVDZ Park, WH de Jong… - International journal …, 2016 - Taylor & Francis
Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because
of their unique physicochemical and biological properties. A major application area of NMs …

Nonclinical regulatory immunotoxicity testing of nanomedicinal products: Proposed strategy and possible pitfalls

C Giannakou, MVDZ Park… - Wiley …, 2020 - Wiley Online Library
Various nanomedicinal products (NMPs) have been reported to induce an adverse immune
response, which may be related to their tendency to accumulate in or target cells of the …

The impact of immunotoxicity in evaluation of the nanomaterials safety

AB Engin, AW Hayes - Toxicology Research and Application, 2018 - journals.sagepub.com
Nanomedicinal products (NMPs), due to their unique properties, are extensively investigated
for their biomedical and pharmaceutical applications. Apart from being carriers of certain …

Interactions of nanomaterials with the immune system

S Hussain, JAJ Vanoirbeek… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
Abstract Evaluation of the immunomodulatory potentials of nanomaterials is essential for
developing safe and consumer‐friendly nanotechnology. Various nanomaterials interact …

Nanomedicinal products: a survey on specific toxicity and side effects

W Brand, CW Noorlander, C Giannakou… - International journal …, 2017 - Taylor & Francis
Due to their specific properties and pharmacokinetics, nanomedicinal products (NMPs) may
present different toxicity and side effects compared to non-nanoformulated, conventional …

Immunological properties of engineered nanomaterials

MA Dobrovolskaia, SE McNeil - Nature nanotechnology, 2007 - nature.com
Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles
that enter the body accidentally. There has been much less research on the toxicology of …

Main trends of immune effects triggered by nanomedicines in preclinical studies

B Halamoda-Kenzaoui… - International journal of …, 2018 - Taylor & Francis
The application of nanotechnology to emerging medicinal products is a crucial parameter for
the implementation of personalized medicine. For example, sophisticated drug delivery …

[HTML][HTML] Lessons learned from immunological characterization of nanomaterials at the Nanotechnology Characterization Laboratory

MA Dobrovolskaia - Frontiers in Immunology, 2022 - frontiersin.org
Nanotechnology carriers have become common in pharmaceutical products because of
their benefits to drug delivery, including reduced toxicities and improved efficacy of active …

Current understanding of interactions between nanoparticles and the immune system

MA Dobrovolskaia, M Shurin, AA Shvedova - Toxicology and applied …, 2016 - Elsevier
The delivery of drugs, antigens, and imaging agents benefits from using nanotechnology-
based carriers. The successful translation of nanoformulations to the clinic involves thorough …

Modulation of immune responses with nanoparticles and reduction of their immunotoxicity

Q Muhammad, Y Jang, SH Kang, J Moon, WJ Kim… - Biomaterials …, 2020 - pubs.rsc.org
Particles with a size range of 1–100 nm used in various fields of life sciences are called
nanoparticles (NPs). Currently, nanotechnology has a wide range of applications in …