Visceral hypersensitivity is a common characteristic in patients suffering from irritable bowel
syndrome (IBS) and other disorders with visceral pain. Although the pathogenesis of visceral …

Visceral hypersensitivity is a major contributor to irritable bowel syndrome and other
disorders with visceral pain. Substantial evidence has established that glial activation and …

Stress can trigger symptoms in patients with irritable bowel syndrome (IBS). Previously we
demonstrated that chronic psychological stress induced microglial remodeling in the central …

Ample evidence suggests that early life stress (ELS) is a high-risk factor for the development
of visceral pain disorders, whereas the mechanism underlying neuronal circuit remains …

Visceral hypersensitivity is a hallmark of many clinical conditions and remains an ongoing
medical challenge. Although the central neural mechanisms that regulate visceral …

Irritable bowel syndrome (IBS) is a common and debilitating gastrointestinal disorder that is
exacerbated by stress and characterized by abdominal pain. Although microglia in the CNS …

Background & Aims Psychological stress is a trigger for the development of irritable bowel
syndrome and associated symptoms including abdominal pain. Although irritable bowel …

The prefrontal cortex plays a key role in the perception of painful stimuli, including those
emerging from the viscera. Colorectal distension is a non-invasive stimulus used to study …

Early life stress (ELS) is a risk factor for developing functional gastrointestinal disorders, and
has been proposed to be related to a central amplification of sensory input and resultant …

Visceral pain is generally poorly localized and characterized by hypersensitivity to a
stimulus such as organ distension. In concert with chronic visceral pain, there is a high …