Branching morphogenesis in the mammary gland is achieved by the migration of epithelial
cells through a microenvironment consisting of stromal cells and extracellular matrix (ECM) …

Galectin-3 is an endogenous mammalian lectin that binds to ABH carbohydrate antigens.
Here we show that galectin-3 is strongly up-regulated during mammary gland involution and …

To define the role of galectin-3 in breast cancer progression, we have used a novel three-
dimensional co-culture system that recapitulates in vivo reciprocal functional breast …

Aberrations in glycan and lectin expression and function represent one of the earliest
hallmarks of cancer. Among galectins, a conserved family of β-galactoside-binding lectins …

Galectin‐3 (Gal‐3) is a multifunctional β‐galactoside‐binding lectin that once synthesized is
expressed in the nucleus, cytoplasm, cell surface, and extracellular environment. Gal‐3 …

Galectin-3 is a glycan-binding protein that mediates cell–cell and/or cell–extracellular matrix
(ECM) interactions. Although galectin-3 is implicated in the progression of various types of …

Galectin-3 has been implicated in tumor progression. We demonstrated
immunohistochemically that Galectin-3 was negative in normal breast tissue, but it was …

Abstract Background Galectin-3 (Gal3) plays diverse roles in cancer initiation, progression,
and drug resistance depending on tumor type characteristics that are also associated with …

Galectin-3 (Gal-3), a 31 kDa member of the family of beta-galactoside-binding proteins, has
been implicated in the progression of different human cancers. However, the proposed roles …

Because of their ability to induce local immunosuppression and to confer cancer cells with
resistance to apoptosis, members of the galectin family are emerging as a new class of …