Despite recent advances, insulin therapy remains a treatment, not a cure, for diabetes
mellitus with persistent risk of glycaemic alterations and life‐threatening complications …

Islet β‐cell replacement and regeneration are two promising approaches for the treatment of
Type 1 Diabetes Mellitus. Indeed, the success of islet transplantation in normalizing blood …

Islet transplantation is an important option in the treatment of type 1 diabetes. However, a
donor shortage and immunosuppressant‐related complications are the current major …

Diabetes mellitus is characterized by the body's inability to control blood glucose levels
within a physiological range due to loss and/or dysfunction of insulin producing beta cells …

Cell replacement therapy using stem-cell-derived insulin-producing β-like cells (sBCs) has
been proposed as a practical cure for patients with type one diabetes (T1D). sBCs can …

Allogeneic islet transplantation serves as a source of insulin-secreting beta-cells for the
maintenance of normal glucose levels and treatment of diabetes. However, limited …

The replacement of insulin‐producing β cells by islet transplantation can efficiently reverse
diabetes. The recent improvements in clinical results were made possible by transplanting …

Diabetes affects 246 million people around the world. To date, no definitive cure has been
discovered. Recent clinical trials have shed light on the possibility of successfully …

Type 1 diabetes results from autoimmune destruction of the insulin‐producing beta cells of
the pancreatic islets of Langerhans. Although developments in exogenous insulin therapy …

Islets are composed mostly of β-cells, and therefore stem cell research has concentrated on
generating purified β-cells, neglecting the other endocrine cell types in the islet. We …