Bone mineral density (BMD) is a quantitative traits used as a surrogate phenotype for the
diagnosis of osteoporosis, a common metabolic disorder characterized by increased fracture …

Throughout life, bone is continuously remodelled to be able to fulfil its multiple functions. The
importance of strictly regulating the bone remodelling process, which is defined by the …

Osteoporosis is a common disease with a strong genetic component characterized by
reduced bone mass, defects in the microarchitecture of bone tissue, and an increased risk of …

The phenotypic trait of high bone mass (HBM) is an excellent example of the nexus between
common and rare disease genetics. HBM may arise from carriage of many 'high bone …

Fractures due to osteoporosis are an increasing healthcare problem in all ageing
communities. A major determinant of fracture risk is bone density, independent of other …

Bone remodelling is an important process both throughout growth and in adult life. The
homeostasis of bone tissue is maintained by the balanced processes of bone resorption and …

Osteoporosis is a common multifactorial disorder of reduced bone mass. The disorder in its
most common form is generalized, affecting the elderly, both sexes, and all racial groups …

Context: Osteoporosis is a common, highly heritable condition that causes substantial
morbidity and mortality, the etiopathogenesis of which is poorly understood. Genetic studies …

Osteoporosis is the most common multifactorial metabolic bone disorder worldwide with a
strong genetic component. In this review, the evidence for a genetic contribution to …

Context: A strong genetic influence on bone mineral density has been long established, and
modern genotyping technologies have generated a flurry of new discoveries about the …