Cancer constitutes a set of diseases with heterogeneous molecular pathologies. However,
there are a number of universal aberrations common to all cancers, one of these being the …

Although it is clear that genetic alterations are critical for the initiation and maintenance of
human cancer, it is also becomingevident that epigenetic changes may be essential for the …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

The classical theory of recessive oncogenesis predicted a mutational mechanism for the
inactivation of tumor suppressor (TS) genes. This prediction has been amply confirmed, but …

Epigenetic mechanisms including DNA and histone modifications result in silencing of
genes without changing the coding sequence of the gene. Even though these events are …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Cancer cells undergo many different alterations during their transformation, including
genetic and epigenetic events. The controlled division of healthy cells can be impaired …

Epigenetic inactivation of genes that are crucial for the control of normal cell growth is a
hallmark of cancer cells. These epigenetic mechanisms include crosstalk between DNA …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …