Like embryonic stem cells, induced pluripotent stem cells (iPSCs) can differentiate into all
three germ layers in an in vitro system. Here, we developed a new technology for obtaining …

Highlights•Human naïve-like cells have been generated.•Human naïve-like cells show close
similarity to mouse naïve cells and human blastocysts.•Molecular differences to mouse naïve …

Human embryonic stem cells (hESCs) present a fascinating and powerful system for
generating specialized cell types of the human body. Culture and directed differentiation of …

Porcine induced pluripotent stem cells (piPSCs) retain the enormous potential for farm
animal reproduction and translational medicine, and have been reported by many …

Non-human primates (NHPs) are similar with humans in their anatomy, physiology, genetics
and neural functions, and in their cognition, emotions and social behavior. The NHP model …

Serum-and 2i-cultured embryonic stem cells (ESCs) show different epigenetic landscapes
and transcriptomic profiles. The difference in the function and expression of microRNAs …

The combination of genome-edited human embryonic stem cells (hESCs) and subsequent
neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the …

Cell surface glycans are tissue-specific and developmentally regulated. They function as
essential modulators in cell-cell interactions, cell-extracellular matrix interactions, and ligand …

Spermatogenic lineage has been directly generated in spermatogonial stem cell (SSC)
conditions from human pluripotent stem cells (PSCs). However, it remains unknown whether …

The reprogramming of human induced pluripotent stem cells (hiPSCs) proceeds in a
stepwise manner with reprogramming factors binding and epigenetic composition changes …