The Activin/Nodal/TGF‐β signaling pathway plays a major role in maintaining mouse
epiblast stem cells (Epi SC s). The Epi SC‐maintaining medium, which contains Activin A …

X chromosome inactivation (XCI) is a strategy used by mammals to silence genes along one
of the two female X chromosomes and equilibrate expression dosage between XY males …

A major goal for stem cell research and its clinical applications is to derive high quality
human pluripotent stem cell (hPSC) lines that recapitulate in culture the properties of …

Purpose of review Pluripotent stem cells (PSCs) have the capacity to differentiate into
various types of cells, and are promising cell sources for regenerative therapy and drug …

Background: Pluripotency of stem cells is an important scientific issue and is attracting great
interest for the broader community, especially for regenerative medicine field. Pluripotent …

Embryonic stem cells (ES cells) can be maintained its undifferentiated state with feeder cells
or LIF, which can activate Jak/Stat3 pathway. Recently, it has been reported a new culture …

Animal development entails the sequential and coordinated specialization of cells. During
cell differentiation, transcription factors, cell signaling pathways, and chromatin-associated …

X-chromosome inactivation is a mammalian epigenetic phenomenon, which occurs during
female embryogenesis and has the purpose to equalize expression of X-chromosomal …

Primed induced pluripotent stem cells (UMN PCBC16iPS)[5] to be used for naive cell
derivation were cultured for at least two passages in mTeSR1 medium (STEMCELL …

During early embryogenesis, cells must exit pluripotency and commit to multiple lineages in
all germ-layers. How this transition is operated in vivo is poorly understood. Here, we report …