Eckol and dieckol are important phlorotannins found in edible brown algae including
Eisenia bicyclis, Ecklonia stolonifera, and others. Inhibition of monoamine oxidase (MAO) …

A new series of diphenylpyrimidine derivatives (SFA-DPPYs) were synthesized by
introducing a functional sulfonamide into the C-2 aniline moiety of pyrimidine template, and …

Two hydrazone ligands 8-quinolinecarbaldehyde 3-methoxybenzoylhydrazone (L1) and 8-
quinolinecarbaldehyde benzoylhydrazone (L2) and the corresponding mononuclear copper …

Drug reprofiling is emerging as an effective paradigm for discovery of cancer treatments.
Herein, an antipsychotic drug is immobilised using the Magic Tag® chemical genomics tool …

We report molecular characterization of the kisspeptin receptor (kiss1r), an essential
gatekeeper for reproduction and onset of puberty in vertebrates. The full-length cDNA …

In this work, we report the multicomponent synthesis of a focused histone deacetylase
(HDAC) inhibitor library with peptoid-based cap groups and different zinc-binding groups. All …

In this study, we investigated curcumin (CUR) solubility profiles and hydration/desolvation
effects of this substance formulated with γ-cyclodextrin (γ-CD) and hydroxypropyl-γ …

Cancer is now the second-leading cause of mortality and morbidity, behind only heart
disease, necessitating urgent development of (chemo) therapeutic interventions to stem the …

Abstract A series of 1-[(methylsulfonyl) methyl]-2-nitro-5, 6, 7, 8-tetrahydroindolizines and
homologs were designed, prepared, and evaluated as non-sugar-type α-glucosidase …

The use of computers for predicting the structures and properties of biomolecules has
closely paralleled computer development since the 1950s, and has been one of the core …