Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders

LGP de Melo, SOV Nunes, G Anderson… - Progress in Neuro …, 2017 - Elsevier
This review examines the shared immune-inflammatory, oxidative and nitrosative stress
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …

Multiple aberrations in shared inflammatory and oxidative & nitrosative stress (IO&NS) pathways explain the co-association of depression and cardiovascular disorder …

M Maes, P Ruckoanich, YS Chang… - Progress in Neuro …, 2011 - Elsevier
There is evidence that there is a bidirectional relationship between major depression and
cardiovascular disorder (CVD): depressed patients are a population at risk for increased …

[PDF][PDF] Depression's multiple comorbidities explained by (neuro) inflammatory and oxidative & nitrosative stress pathways

M Maes, M Kubera, E Obuchowiczwa… - Neuroendocrinol …, 2011 - researchgate.net
There is now evidence that depression, as characterized by melancholic symptoms, anxiety,
and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell …

Major differences in neurooxidative and neuronitrosative stress pathways between major depressive disorder and types I and II bipolar disorder

M Maes, K Landucci Bonifacio, NR Morelli… - Molecular …, 2019 - Springer
Accumulating evidence indicates that oxidative and nitrosative stress (O&NS) pathways play
a key role in the pathophysiology of bipolar disorder (BD) and major depressive disorder …

An intriguing and hitherto unexplained co-occurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative …

M Maes - Progress in Neuro-Psychopharmacology and …, 2011 - Elsevier
There is a significant 'comorbidity'between depression and myalgic encephalomyelitis/
chronic fatigue syndrome (ME/CFS). Depressive symptoms frequently occur during the …

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

G Morris, BK Puri, AJ Walker, M Maes… - Neuroscience & …, 2019 - Elsevier
Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and
consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric …

Towards a “metabolic” subtype of major depressive disorder: shared pathophysiological mechanisms may contribute to cognitive dysfunction

CS Liu, AF Carvalho… - CNS & Neurological …, 2014 - ingentaconnect.com
Major depressive disorder (MDD) is frequently associated with significant cognitive
dysfunction. Furthermore, MDD is often co-morbid with obesity and metabolic disorders. The …

Central and peripheral inflammation link metabolic syndrome and major depressive disorder

KL Chan, F Cathomas, SJ Russo - Physiology, 2019 - journals.physiology.org
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …

Oxidative & nitrosative stress in depression: why so much stress?

S Moylan, M Berk, OM Dean, Y Samuni… - Neuroscience & …, 2014 - Elsevier
Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the
pathophysiology of unipolar and bipolar depression. These disorders are characterized inter …

Generalized anxiety disorder (GAD) and comorbid major depression with GAD are characterized by enhanced nitro-oxidative stress, increased lipid peroxidation, and …

M Maes, KL Bonifacio, NR Morelli, HO Vargas… - Neurotoxicity …, 2018 - Springer
Accumulating evidence shows that nitro-oxidative pathways play an important role in the
pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD) and maybe …