Bipolar disorder and immune dysfunction: epidemiological findings, proposed pathophysiology and clinical implications

JD Rosenblat, RS McIntyre - Brain sciences, 2017 - mdpi.com
Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …

Bipolar disorder and inflammation

JD Rosenblat, RS McIntyre - Psychiatric Clinics, 2016 - psych.theclinics.com
Methods For this narrative clinical overview, the MEDLINE/PubMed, Embase, Google
Scholar and ClinicalTrials. gov databases were searched from inception through June 2015 …

The immunology of bipolar disorder

IG Barbosa, R Machado-Vieira, JC Soares… - …, 2014 - karger.com
Bipolar disorder (BD) is a psychiatric condition associated with elevated frequency of clinical
comorbidities and cognitive impairment. The neurobiology of BD is not completely …

Monocyte and lymphocyte activation in bipolar disorder: a new piece in the puzzle of immune dysfunction in mood disorders

IG Barbosa, NP Rocha, F Assis… - International Journal …, 2015 - academic.oup.com
Background: This study tested the hypothesis that the low-grade inflammation presented in
patients with bipolar disorder (BD) is associated with expansion of activated T cells, and this …

Neuroinflammation in bipolar depression

F Benedetti, V Aggio, ML Pratesi, G Greco… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …

Revisiting inflammation in bipolar disorder

GR Fries, C Walss-Bass, ME Bauer… - … Biochemistry and Behavior, 2019 - Elsevier
Bipolar disorder (BD) has been associated with immune changes, and yet their underlying
mechanisms are still not fully understood. Here, we review the current state of the field …

Medical comorbidity in bipolar disorder: the link with metabolic-inflammatory systems

A SayuriYamagata, E Brietzke, JD Rosenblat… - Journal of Affective …, 2017 - Elsevier
Background Bipolar disorder (BD) is associated with chronic low-grade inflammation,
several medical comorbidities and a decreased life expectancy. Metabolic-inflammatory …

Are medical comorbid conditions of bipolar disorder due to immune dysfunction?

JD Rosenblat, RS McIntyre - Acta Psychiatrica Scandinavica, 2015 - Wiley Online Library
Objective Epidemiological data have shown a clear association between bipolar disorder
(BD) and medical comorbidities. The aim of this article was to assess the evidence of …

Inflammation as a neurobiological substrate of cognitive impairment in bipolar disorder: evidence, pathophysiology and treatment implications

JD Rosenblat, E Brietzke, RB Mansur… - Journal of affective …, 2015 - Elsevier
Background Bipolar disorder (BD) has been associated with cognitive impairment during
depressed, manic and euthymic periods. Inflammation has been shown to be involved in the …

Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications

N Hamdani, R Doukhan, O Kurtlucan… - Current psychiatry …, 2013 - Springer
Bipolar disorder is now known to be associated not only with highly prevalent co-occurring
psychiatric and substance use disorders but also with medical comorbidities, such as …