Alcohol use disorders (AUDs) are thought to result from complex interplay between genetic
and environmental factors, but the exact neurobiological underpinnings of these disorders …

It is common knowledge and has been shown in studies that alcoholism clusters in families.
However, the model of inheritance in vulnerability to alcoholism is believed to be complex …

Alcoholism is a complex disorder with symptoms ranging from abuse to dependence, often
comorbid with depression, antisocial personality, or anxiety. Neurodevelopmental causes of …

Prospects for research advances in alcoholism are very promising, because of the explosion
in the neurosciences and advances in epidemiology and typology of the disorder. For …

Alcohol is a widely used and abused psychoactive drug in Western societies. Long-term
consumption may lead to alcohol addiction, a severe psychiatric disorder. The serotonergic …

Cloninger proposed a neurochemical model of alcoholism suggesting that type 2 alcoholics
have serotonergic deficits with intact dopaminergic system, whereas the type 1 alcoholics …

Several studies support the assumption that the development and/or maintenance of
alcoholism is due to a deficit of the central serotonergic system. But it still remains open …

Alcoholism is a multifactorial neuropsychiatric disorder with complex mode of inheritance. It
is governed by the combination of psychological, social, and genetic factors [Heath, 1995; …

Background Type 2 alcoholism is characterized by low serotonin system functioning and has
a high degree of heritability, with offspring of alcoholics often showing a reduced response …

The majority of studies that have examined the usefulness of pharmacotherapies selective
for serotonin (5-hydroxytryptamine; 5-HT) as a treatment for alcohol dependence have been …