Sequentially-crosslinked bioactive hydrogels as nano-patterned substrates with customizable stiffness and degradation for corneal tissue engineering applications

M Rizwan, GSL Peh, HP Ang, NC Lwin, K Adnan… - Biomaterials, 2017 - Elsevier
Naturally-bioactive hydrogels like gelatin provide favorable properties for tissue-engineering
but lack sufficient mechanical strength for use as implantable tissue engineering substrates …

Biochemically and topographically engineered poly (ethylene glycol) diacrylate hydrogels with biomimetic characteristics as substrates for human corneal epithelial …

B Yanez‐Soto, SJ Liliensiek… - Journal of biomedical …, 2013 - Wiley Online Library
Incorporation of biophysical and biochemical cues into the design of biomaterials is an
important strategy for tissue engineering, the design of biomedical implants and cell culture …

Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications

S Sharifi, MM Islam, H Sharifi, R Islam, D Koza… - Bioactive materials, 2021 - Elsevier
Gelatin based adhesives have been used in the last decades in different biomedical
applications due to the excellent biocompatibility, easy processability, transparency, non …

[HTML][HTML] 3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

B He, J Wang, M Xie, M Xu, Y Zhang, H Hao, X Xing… - Bioactive materials, 2022 - Elsevier
Corneal regeneration has always been a challenge due to its sophisticated structure and
undesirable keratocyte-fibroblast transformation. Herein, we propose 3D printing of a …

In situ-forming collagen hydrogel crosslinked via multi-functional PEG as a matrix therapy for corneal defects

GM Fernandes-Cunha, KM Chen, F Chen, P Le… - Scientific reports, 2020 - nature.com
Visually significant corneal injuries and subsequent scarring collectively represent a major
global human health challenge, affecting millions of people worldwide. Unfortunately, less …

Composite electrospun gelatin fiber-alginate gel scaffolds for mechanically robust tissue engineered cornea

K Tonsomboon, ML Oyen - Journal of the mechanical behavior of …, 2013 - Elsevier
A severe shortage of good quality donor cornea is now an international crisis in public
health. Alternatives for donor tissue need to be urgently developed to meet the increasing …

[HTML][HTML] Cell loaded 3D bioprinted GelMA hydrogels for corneal stroma engineering

CK Bektas, V Hasirci - Biomaterials science, 2020 - pubs.rsc.org
Tissue engineering aims to replace missing or damaged tissues and restore their functions.
Three-dimensional (3D) printing has been gaining more attention because it enables the …

Gelatin-methacryloyl hydrogels: towards biofabrication-based tissue repair

BJ Klotz, D Gawlitta, AJWP Rosenberg, J Malda… - Trends in …, 2016 - cell.com
Research over the past decade on the cell–biomaterial interface has shifted to the third
dimension. Besides mimicking the native extracellular environment by 3D cell culture …

Mimicking corneal stroma using keratocyte‐loaded photopolymerizable methacrylated gelatin hydrogels

C Kilic Bektas, V Hasirci - Journal of tissue engineering and …, 2018 - Wiley Online Library
Cell‐laden methacrylated gelatin (GelMA) hydrogels with high (approximately 90%)
transparency were prepared to mimic the natural form and function of corneal stroma. They …

Crosslinked collagen–gelatin–hyaluronic acid biomimetic film for cornea tissue engineering applications

Y Liu, L Ren, Y Wang - Materials Science and Engineering: C, 2013 - Elsevier
Cornea disease may lead to blindness and keratoplasty is considered as an effective
treatment method. However, there is a severe shortage of donor corneas worldwide. This …