Lubricin, a heavily O-glycosylated protein, is essential for boundary lubrication of articular
cartilage. Strong surface adherence of lubricin is required given the extreme force it must …

Objective Understanding the cartilage surface structure, lost in arthritic disease, is essential
for developing strategies to effectively restore it. Given that adherence of the lubricating …

Lubricin is a secreted, cytoprotective glycoprotein that contributes to the essential boundary
lubrication mechanisms necessary for maintaining low friction levels at articular cartilage …

Hypothesis Synovial surfaces are lubricated by biomolecular aggregates that act in synergy,
and lubricin is one key biolubricant. Its molecular structure allows extensive hydration and …

One of the major constituents of the synovial fluid that is thought to be responsible for
chondroprotection and boundary lubrication is the glycoprotein lubricin (PRG4); however …

Osteoarthritis (OA) is a multi-factor disorder of sinovial joints, which characterized by
escalated degeneration and loss of articular cartilage. Treatment of OA is a critical unmet …

Purpose of review: Understanding lubrication of articular cartilage, provided by synovial
fluid, requires knowledge of tribology, cartilage mechanics, biochemistry, and now genetic …

Osteoarthritis (OA) is characterized by degenerative changes within joints that involved
quantitative and/or qualitative alterations of cartilage and synovial fluid lubricin, a mucinous …

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin,
a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how …

Lubricin (LUB) is a glycoprotein of the synovial cavity of human articular joints, where it
serves as an antiadhesive, boundary lubricant, and regulating factor for the cartilage …