B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple
sclerosis (MS). This notion is supported by various immunological changes observed in MS …

Over the last decade, evidence condensed that B cells, B cell-derived plasma cells and
antibodies play a key role in the pathogenesis and progression of multiple sclerosis (MS). In …

Recent years have substantially broadened our view on the pathogenesis of multiple
sclerosis (MS). While earlier concepts focused predominantly on T lymphocytes as the key …

Increasing evidence has suggested that both antibody-dependent and antibody-
independent functions of B cells are involved in multiple sclerosis (MS). The contrasting …

There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …

While it was long held that T cells were the primary mediators of multiple sclerosis (MS)
pathogenesis, the beneficial effects observed in response to treatment with Rituximab (RTX) …

Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …

Multiple sclerosis (MS) is a chronic inflammatory neurological disease of the CNS that goes
along with demyelination and neurodegeneration. It is probably caused by an autoimmune …

The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

Background: Collectively, research on the role of B-cells in the pathogenesis of multiple
sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic …