Optimized temporal pattern of brain stimulation designed by computational evolution
Brain stimulation is a promising therapy for several neurological disorders, including
Parkinson's disease. Stimulation parameters are selected empirically and are limited to the …
Parkinson's disease. Stimulation parameters are selected empirically and are limited to the …
Phasic burst stimulation: a closed-loop approach to tuning deep brain stimulation parameters for Parkinson's disease
We propose a novel, closed-loop approach to tuning deep brain stimulation (DBS) for
Parkinson's disease (PD). The approach, termed Phasic Burst Stimulation (PhaBS), applies …
Parkinson's disease (PD). The approach, termed Phasic Burst Stimulation (PhaBS), applies …
Toward closed-loop optimization of deep brain stimulation for Parkinson's disease: concepts and lessons from a computational model
X Feng, B Greenwald, H Rabitz… - Journal of neural …, 2007 - iopscience.iop.org
Deep brain stimulation (DBS) of the subthalamic nucleus with periodic, high-frequency pulse
trains is an increasingly standard therapy for advanced Parkinson's disease. Here, we …
trains is an increasingly standard therapy for advanced Parkinson's disease. Here, we …
Model-based analysis and design of waveforms for efficient neural stimulation
WM Grill - Progress in brain research, 2015 - Elsevier
The design space for electrical stimulation of the nervous system is extremely large, and
because the response to stimulation is highly nonlinear, the selection of stimulation …
because the response to stimulation is highly nonlinear, the selection of stimulation …
Computational modeling of neurostimulation in brain diseases
Neurostimulation as a therapeutic tool has been developed and used for a range of different
diseases such as Parkinson's disease, epilepsy, and migraine. However, it is not known why …
diseases such as Parkinson's disease, epilepsy, and migraine. However, it is not known why …
An improved genetic algorithm for designing optimal temporal patterns of neural stimulation
Objective. Electrical neuromodulation therapies typically apply constant frequency
stimulation, but non-regular temporal patterns of stimulation may be more effective and more …
stimulation, but non-regular temporal patterns of stimulation may be more effective and more …
[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …
Semi-automated approaches to optimize deep brain stimulation parameters in Parkinson's disease
Background Deep brain stimulation (DBS) is a treatment option for Parkinson's disease
patients when medication does not sufficiently manage their symptoms. DBS can be a highly …
patients when medication does not sufficiently manage their symptoms. DBS can be a highly …
Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease
High frequency deep brain stimulation is an effective therapy for motor symptoms in
Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular …
Parkinson's disease. However, the relative clinical efficacy of regular versus non-regular …
Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement
S Santaniello, MM McCarthy… - Proceedings of the …, 2015 - National Acad Sciences
High-frequency deep brain stimulation (HFS) is clinically recognized to treat parkinsonian
movement disorders, but its mechanisms remain elusive. Current hypotheses suggest that …
movement disorders, but its mechanisms remain elusive. Current hypotheses suggest that …