Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an
autoimmune response against central nervous system (CNS) structures. Traditionally …

Multiple sclerosis (MS) is a chronic inflammatory neurological disease of the CNS that goes
along with demyelination and neurodegeneration. It is probably caused by an autoimmune …

Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central
nervous system (CNS) that traditionally has been considered to be mediated primarily by T …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Several clinical trials have demonstrated the efficacy of lytic therapies targeting B cells in the
treatment of relapsing multiple sclerosis (MS). More modest efficacy has been noted in the …

Increasing evidence suggests that B cells contribute both to the regulation of normal
autoimmunity and to the pathogenesis of immune mediated diseases, including multiple …

B cells play a vital function in multiple sclerosis (MS) pathogenesis through an array of
effector functions. All currently approved MS disease–modifying therapies alter the …

Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …

Introduction: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system. The latest development of B-cell depletion by anti-CD20 monoclonal antibodies has …

The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …