The seminal work of Grinvald et al. has paved the way for the use of intrinsic optical signals
measured with reflection methods for the analysis of brain function. Although this work has …

Optical methods have been used to measure physiological variables for decades, as is
apparent from other chapters in this book. However, the use of diffuse optical light for …

The present work describes the use of noninvasive diffuse optical tomography (DOT)
technology to measure hemodynamic changes, providing relevant information which helps …

This review describes the unique opportunities and challenges for noninvasive optical
mapping of human brain function. Diffuse optical methods offer safe, portable, and radiation …

Monitoring brain function with light in vivo has become a reality. The technology of detecting
and interpreting patterns of reflected light has reached a degree of maturity that now permits …

Functional near infrared spectroscopy (fNIRS) is a portable monitor of cerebral
hemodynamics with wide clinical potential. However, in fNIRS, the vascular signal from the …

The cerebral microvasculature consists of pial vascular networks, parenchymal descending
arterioles, ascending venules and parenchymal capillaries. This vascular …

Diffuse optical spectroscopy is a noninvasive method that uses low levels of near-infrared
light to measure blood oxygenation in the brain. Over the last 35 years, the number of diffuse …

Near-Infrared Spectroscopy (NIRS) and diffuse optical imaging (DOI) are increasingly used
to detect hemodynamic changes in the cerebral cortex induced by brain activity. Until …

Diffuse optical tomography (DOT) is a functional brain imaging technique that measures
cerebral blood oxygenation and blood volume changes. This technique is particularly useful …