A collective century of discoveries establishes the importance of the renin angiotensin
aldosterone system in maintaining blood pressure, fluid volume and electrolyte homeostasis …

BACKGROUND: The renin-angiotensin aldosterone system (RAAS) is a hormonal cascade
that functions in the homeostatic control of arterial pressure, tissue perfusion, and …

The renin-angiotensin-aldosterone system (RAAS) is activated in hypertension, cardiac and
renal disease and is attributed as a major factor in the morbidity and mortality associated …

Angiotensin II plays a central role in the regulation of systemic arterial pressure through its
systemic synthesis via the renin-angiotensin-aldosterone cascade. It acts directly on …

Since the initial description of angiotensin II–mediated hypertension 40 years ago, basic and
clinical investigations of the renin-angiotensin system (RAS) have resulted in a broader …

Although significant advances have been made in the therapeutic blockade of the renin–
angiotensin–aldosterone system (RAAS) using angiotensin-converting enzyme (ACE) …

The renin-angiotensin-aldosterone system (RAAS) plays an integral role in maintaining
vascular tone, optimal salt and water homeostasis, and cardiac function in humans …

Background The renin-angiotensin system consists of a cascade of substrate-enzyme
interactions that culminates with the production of angiotensin II, the active peptide …

The renin-angiotensin system (RAS) is undisputedly one of the most prominent endocrine
(tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) vasoactive …

Effective antihypertensive therapy has made a major contribution to the reductions in the
morbidity and mortality of cardiovascular disease that have been achieved since the 1960s …