Restoration of blood flow to myocardium previously subjected to ischemia leads to
ischemia/reperfusion injury due to oxidative stress. An increased production of toxic …

The heart is a target organ for oxidative stress-related injuries. Because of its very high
energetic metabolic demand, the heart has the highest rate of production of reactive oxygen …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) formation increases in
the post-ischemic myocardium and represents a mechanism of post ischemic injury. ROS …

Oxidative stress is a condition in which oxidant metabolites exert their toxic effect because of
an increased production or an altered cellular mechanism of protection. The heart needs …

For more than a decade, our laboratory has investigated the significance of oxygen derived-
free radicals during myocardial ischemia/reperfusion in several animal [1–6] and clinical [7] …

Cardiac ischemia, followed by reperfusion, often results in the development of cardiac
contractile dysfunction that limits the recovery prognosis of patients. The current goal of …

Objectives. Coronary reperfusion procedure leads to ischemia/reperfusion injury of the heart
(IRI). IRI arises from increased degradation of myosin light chains and increased activity of …

In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by
angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the …

Reperfusion through thrombolysis or percutananeous coronary angioplasty is standard
treatment in impending acute myocardial infarction. Although restoration of blood flow to the …

Heart disease is one of the major health problems of advanced as well as developing
countries of the world. Extensive research through the last decade has shown beyond doubt …