Objective This article reviews and compares four commonly used approaches to assess
patient responsiveness with a treatment or therapy (return to normal (RTN), minimal …

Purpose The recommended method for establishing a meaningful threshold for individual
changes in patient-reported outcome (PRO) scores over time uses an anchor-based …

OBJECTIVE: To identify new cut-off values beyond which patients can be considered as
satisfied or as responders through patient acceptable symptom state (PASS) and OMERACT …

OBJECTIVE: The objective of this review is to summarize recommendations on methods for
evaluating responsiveness and minimal important difference (MID) for patient-reported …

Patient-reported outcomes (PROs) are accepted endpoints in the evaluation of patient
treatment. Attention has focused on defining the minimal clinically important …

Purpose The notion of what constitutes meaningful differences or changes in patient-
reported outcome scores is represented by meaningful change thresholds (MCTs). Applying …

Objective. To examine the influence of different analytical methods, baseline covariates,
followup periods, and anchor questions when establishing a minimal important difference …

Background: For patient-reported outcome measures (PROMs) to provide meaningful
information to support clinical care, we need to understand the magnitude of change that …

Patient reported outcomes provide the patient's perspective on the effectiveness of
treatment. The draft Food and Drug Administration guidance on patient reported outcomes …

Background When evaluating the results of clinical research studies, readers need to know
that patients perceive effect sizes, not p values. Knowing the minimum clinically important …