Tumor-targeted delivery of anticancer drugs using dendrimers has been recognized as a
promising strategy to increase efficiency and reduce adverse effects of chemotherapy …

While reshaping their microenvironment, tumors are also capable of influencing systemic
processes including myeloid cell production. Therefore, the tumor-induced myeloid cells …

To achieve liver-specific delivery of antitumor drug doxorubicin (DOX), PEGylated dendrimer-
DOX conjugates were designed and synthesized, whereas DOX was conjugated to …

Stimuli-responsive peptide dendrimer-drug conjugates have presented significant potential
for cancer therapy. To develop an effective nanoscale chemotherapeutic prodrug, we …

The dense fibrotic stroma in pancreatic ductal adenocarcinoma (PDA) resists drug diffusion
into the tumor and leads to an unsatisfactory prognosis. To address this problem, we …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with no efficacious treatment.
The application of nanomedicine is expected to bring new hope to PDAC treatment. In this …

The objective of the present investigation was to assess the tumor-targeting potential of
ligand-spacer-engineered poly (propylene imine)(PPI) dendrimers as nanoscale drug …

The clinical success of therapeutic DNA is still hindered due to the lack of effective delivery
carriers. Here, we designed a tumor-targeted gene nano delivery system based on EGFR …

Aim: In spite of numerous biopharmaceutical applications of fifth-generation poly
(propyleneimine)(PPI) dendrimers, inherent toxicity due to the presence of many peripheral …

Dendrimer, a new class of hyper-branched polymer with predetermined molecular weight
and well-controlled size, has received much attention in nanobiomedical applications such …