Widespread gene transfer to the retina is challenging as it requires vector systems to
overcome physical and biochemical barriers to enter and diffuse throughout retinal tissue …

Inherited retinal degenerative diseases are a clinically promising focus of adeno-associated
virus (AAV)–mediated gene therapy. These diseases arise from pathogenic mutations in …

Many adeno-associated virus (AAV) serotypes efficiently transduce the retina when
delivered to the subretinal space but show limited success when delivered to the vitreous …

Since their discovery over 55 years ago, adeno-associated virus (AAV) vectors have
become powerful tools for experimental and therapeutic in vivo gene delivery, particularly in …

Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of
viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting …

Adeno-associated virus (AAV) vectors are showing promise in gene therapy trials and have
proven to be extremely efficient biological tools in basic neuroscience research. One major …

Purpose In an earlier study we found normal adeno-associated viral vector type 2 (AAV2)-
mediated GFP expression after intravitreal injection to one eye of normal C57BL/6J mice …

Background Adeno-associated virus (AAV) is well established as a vehicle for in vivo gene
transfer into the mammalian retina. This virus is promising not only for gene therapy of retinal …

Gene therapy vectors based on adeno-associated viruses (AAVs) show promise for the
treatment of retinal degenerative diseases. In prior work, subretinal injections of AAV2 …

Purpose: We recently demonstrated that direct subretinal (SR) injection of adeno-associated
virus (AAV) type 8 (AAV8) into photoreceptor cells and retinal pigment epithelium (RPE) is a …