7. Cossarizza A., et al. 1996. CD45 isoforms expression on CD4+ and CD8+ T cells
throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing …

T cells are mononuclear white blood cells that are derived from bone marrow stem cells that
have undergone maturation in the thymus (hence the terms ''thymus-derived''or ''T cells'') and …

Mechanisms of central tolerance in the thymus and peripheral tolerance are in place to
control autoreactive T cells and to prevent the development of autoimmune disease. We …

Purpose Thymus is the site of T-cell development and is essential for the induction of self-
tolerance, by deletion of autoreactive T lymphocytes (negative selection) and by generation …

The immune response is finely tuned to the various invaders that may cause damage and
disease. There is an innate immune system and an acquired immune response, but there is …

CD4 helper T cells can be divided into Th1 and Th2 subsets based upon the cytokines they
produce. Th1 and Th2 cells have been found to be mutually antagonistic, leading to either …

The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …

T cell subsets in infectious and autoimmune diseases Page 1 cal» Fomdnfion Symposium ws 0 I
cm SUBSETS IN INFECTIOUS AND AUTOIMMUNI DISEASES Fnundulwn imam» Foundation bu …

T cells bearing receptors with high affinity for self-antigens are responsible for the
generation of autoimmune diseases. Therefore, potentially autoreactive thymocytes must be …