Philadelphia chromosome (Ph)–like B-cell acute lymphoblastic leukemia (Ph-like ALL) is
associated with activated JAK/STAT, Abelson kinase (ABL), and/or phosphatidylinositol 3 …

Abstract CRLF2 rearrangements, JAK1/2 point mutations, and JAK2 fusion genes have been
identified in Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL), a …

Purpose Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy
resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) …

Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL …

Recent investigations have documented that constitutively activated phosphatidylinositol 3-
kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is a common feature of …

Recent findings have highlighted that constitutively active phosphatidylinositol 3-kinase
(PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling is a common feature of T-cell …

Background Although in recent years, the introduction of novel chemotherapy protocols has
improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients, refractory …

Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described
subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well …

Constitutively active phosphoinositide 3-kinase (PI3K) signaling is a common feature of T-
cell acute lymphoblastic leukemia (T-ALL), where it upregulates cell proliferation, survival …

B-precursor acute lymphoblastic leukemia (B-pre ALL) is a malignant disorder characterized
by the abnormal proliferation of B-cell progenitors. The prognosis of B-pre ALL has improved …