Emerging Data Strengthens the Argument That the Microbiome Is the Fifth Horseman of the Drug Discovery Apocalypse
CW Lindsley - ACS Chemical Neuroscience, 2017 - ACS Publications
In a recent editorial, 1 I discussed a report in Science that described the influence of
individual vaginal microbiomes on drug efficacy and HIV acquisition, 2 and the implications …
individual vaginal microbiomes on drug efficacy and HIV acquisition, 2 and the implications …
Is the Microbiome the Fifth Horseman of the Apocalypse in Drug Discovery? Implications for the Gut–Brain Axis
JA Conrad, CW Lindsley - ACS Chemical Neuroscience, 2017 - ACS Publications
In drug discovery and development, lore abounds for the Four Horsemen of the
Apocalypse:(1) Bioavailability in man,(2) Metabolism in man;(3) Toxicology in man, and (4) …
Apocalypse:(1) Bioavailability in man,(2) Metabolism in man;(3) Toxicology in man, and (4) …
Chemotherapy, immunity and microbiota–a new triumvirate
In little over 5 years, microbiome research has moved from simple, yet technically
challenging, cartographic projects to stunning functional research linking commensal …
challenging, cartographic projects to stunning functional research linking commensal …
Targeting strategies for chemotherapy-induced peripheral neuropathy: does gut microbiota play a role?
S Zhong, Z Zhou, Y Liang, X Cheng, Y Li… - Critical reviews in …, 2019 - Taylor & Francis
Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive, often irreversible
condition that produces severe neurological deficits. Emerging data suggest that …
condition that produces severe neurological deficits. Emerging data suggest that …
Dominant role of the gut microbiota in chemotherapy induced neuropathic pain
C Ramakrishna, J Corleto, PM Ruegger, GD Logan… - Scientific reports, 2019 - nature.com
Chemotherapy induced peripheral neuropathy (CIPN), a toxic side effect of some cancer
treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of …
treatments, negatively impacts patient outcomes and drastically reduces survivor's quality of …
[引用][C] The role of the microbiome in central nervous system clinical pharmacology: more than a gut feeling
PH van der Graaf - Clinical Pharmacology & Therapeutics, 2020 - Wiley Online Library
The microbial communities (bacteria, archaea, small eukaryotes, fungi, and viruses) residing
within human tissues and fluids are individually referred to as microbiota and their collective …
within human tissues and fluids are individually referred to as microbiota and their collective …
Pharmacomicrobiomics in anticancer therapies: why the gut microbiota should be pointed out
Anticancer treatments have shown a variable therapeutic outcome that may be partly
attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent …
attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent …
Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects
Introduction The gut microbiota is involved in host physiology and health. Reciprocal
microbiota-drug interactions are increasingly recognized as underlying some individual …
microbiota-drug interactions are increasingly recognized as underlying some individual …
Gut microbes join the fight against cancer
G Guglielmi - Nature, 2018 - nature.com
Cancer has been a late bloomer in the microbiome revolution that has surged through
biomedicine. Over the past few decades, scientists have linked the gut's composition of …
biomedicine. Over the past few decades, scientists have linked the gut's composition of …
[HTML][HTML] Unraveling the Role of Gut Microbiota in Cancer: Harnessing Probiotics for Anticancer Therapies
S Hajgude - eumr.org
The human microbiota has been implicated in the development of several diseases,
including diabetes and neurodegenerative diseases. Growing recognition of these …
including diabetes and neurodegenerative diseases. Growing recognition of these …