Rethinking ovarian cancer genomics: where genome-wide association studies stand?

R Pinto, J Assis, A Nogueira, C Pereira… - …, 2017 - Taylor & Francis
Genome-wide association studies (GWAS) allow the finding of genetic variants associated
with several traits. Regarding ovarian cancer (OC), 15 GWAS have been conducted since …

MassArray analysis of genomic susceptibility variants in ovarian cancer

S Verma, I Sharma, V Sharma, A Bhat, R Shah… - Scientific Reports, 2020 - nature.com
Ovarian cancer (OC), a multifaceted and genetically heterogeneous malignancy is one of
the most common cancers among women. The aim of the study is to unravel the genetic …

Functional landscape of common variants associated with susceptibility to epithelial ovarian cancer

PCM Lyra, LB Rangel, ANA Monteiro - Current Epidemiology Reports, 2020 - Springer
Abstract Purpose of the Review To date, genome-wide association studies (GWASs) have
identified 39 genomic loci associated with risk of epithelial ovarian cancer at genome-wide …

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer

PDP Pharoah, YY Tsai, SJ Ramus, CM Phelan… - Nature …, 2013 - nature.com
Genome-wide association studies (GWAS) have identified four susceptibility loci for
epithelial ovarian cancer (EOC), with another two suggestive loci reaching near genome …

The prospect of discovering new biomarkers for ovarian cancer based on current knowledge of susceptibility loci and genetic variation

MK Christophersen, C Høgdall… - … Journal of Molecular …, 2019 - spandidos-publications.com
Ovarian cancer is the most lethal gynaecological malignancy. The cancer initially presents
with non‑specific symptoms; thus, it is typically not discovered until the patient has reached …

Common genetic variation and susceptibility to ovarian cancer: current insights and future directions

SP Kar, A Berchuck, SA Gayther, EL Goode… - … Biomarkers & Prevention, 2018 - AACR
In this review, we summarize current progress in the genetic epidemiology of epithelial
ovarian cancer (EOC), focusing exclusively on elucidating the role of common germline …

Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies

H Zhao, J Shen, D Wang, S Gregory, L Medico, Q Hu… - PloS one, 2012 - journals.plos.org
Functional genetic variations play important roles in shaping phenotypic differences among
individuals through affecting gene expression, and thus, very likely to influence disease …

[HTML][HTML] Association analysis of a chemo-response signature identified within the Cancer genome atlas aimed at predicting genetic risk for chemo-response in ovarian …

EA Salinas, AM Newtson, KK Leslie… - … Journal of Molecular …, 2016 - ncbi.nlm.nih.gov
Background: A gene signature associated with chemo-response in ovarian cancer was
created through integration of biological data in The Cancer Genome Atlas (TCGA) and …

Genome-wide association study for ovarian cancer susceptibility using pooled DNA

Y Lu, X Chen, J Beesley, SE Johnatty… - Twin Research and …, 2012 - cambridge.org
Recent Genome-Wide Association Studies (GWAS) have identified four low-penetrance
ovarian cancer susceptibility loci. We hypothesized that further moderate-or low-penetrance …

A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants

S Kim, M Wang, JP Tyrer, A Jensen… - … journal of cancer, 2019 - Wiley Online Library
As a follow‐up to genome‐wide association analysis of common variants associated with
ovarian carcinoma (cancer), our study considers seven well‐known ovarian cancer risk …