Mammalian colonic epithelia consist of cells that are capable of both absorbing and
secreting Cl-. The present studies employing Ussing chamber technique identified two …

Adrenaline activates transient Cl− secretion and sustained K+ secretion across isolated
distal colonic mucosa of guinea‐pigs. The Ca2+‐activated Cl− channel inhibitor CaCCinh …

BACKGROUND & AIMS: The fluid secretion model predicts that intestinal obstruction
disorders can be alleviated by promoting epithelial Cl− secretion. The adenosine 3′, 5 …

Cell-attached recordings revealed Cl− channel activity in basolateral membrane of guinea
pig distal colonic crypts isolated from basement membrane. Outwardly rectified currents …

The mechanisms of anion transport in the rabbit distal colon were investigated in vitro under
short-circuit conditions by examining the effects of transport inhibitors (the stilbene …

We evaluated the effects of clotrimazole and clofibrate on Ca (2+)-and adenosine 3', 5'-cyclic
monophosphate (cAMP)-mediated Cl-secretion in the colonic cell line, T84. We used 1-ethyl …

Background & Aims: Phenylimidazothiazoles have recently been shown to activate wild-type
and mutant cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channels in …

1-Ethyl-2-benzimidazolone (EBIO) caused a sustained increase in electrogenic Cl−
secretion in isolated mouse colon mucosae, an effect reduced by blocking basolateral K+ …

K+ and Cl− conductances and their putative regulation have been characterized in the rat
colonic epithelium by Ussing-chamber experiments, whole-cell and single-channel patch …

In a previous study [Lohrmann et al: Pflügers Arch Eur J Physiol 1995; 429: 517-530] we
have shown that chromanol K+ channel blockers inhibit Cl–secretion in rabbit colon. Their …