Mammalian SWI/SNF (BAF) chromatin remodeling complexes orchestrate a diverse set of
chromatin alterations which impact transcriptional output. Recent whole-exome sequencing …

SWI/SNF is a multisubunit chromatin-remodeling complex that performs fundamental roles in
gene regulation, cell lineage specification, and organismal development. Mutations that …

The genomics-era search for cancer-causing mutations has identified subunits of SWI/SNF
(BAF) chromatin remodeling complexes as major targets of mutation. The mechanism by …

Abstract Mammalian SWI/SNF (BAF) chromatin remodeling complexes play critical roles in
maintaining chromatin architecture and gene expression. Genomic sequencing efforts over …

The SWI/SNF chromatin remodeling complex uses the energy of ATP hydrolysis to alter
contacts between DNA and nucleosomes, allowing regions of the genome to become …

SWI/SNF chromatin remodeling complexes are pleomorphic multisubunit cellular machines
that utilize the energy of ATP hydrolysis to modulate chromatin structure. The complexes …

Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Cancer genome sequencing efforts have revealed the novel theme that chromatin modifiers
are frequently mutated across a wide spectrum of cancers. Mutations in genes encoding …

Multi-subunit ATPase-dependent chromatin remodelling complexes SWI/SNF
(switch/sucrose non-fermentable) are fundamental epigenetic regulators of gene …

Introduction: Cancer genome sequencing studies have discovered mutations in members of
the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly …