Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents …

S Li, D Wei, Z Mao, L Chen, X Yan, Y Li, S Dong… - Bioorganic …, 2017 - Elsevier
Neuroprotection refers to the relative preservation of neuronal structure and function.
Neuroprotective agents refer to substances that are capable of preserving brain function and …

A potent multi-functional neuroprotective derivative of tetramethylpyrazine

HY Chen, DP Xu, GL Tan, W Cai, GX Zhang… - Journal of molecular …, 2015 - Springer
Neurodegenerative disorders are one of the leading causes of death among the elderly.
Therapeutic approaches with a single target have proven unsuccessful in treating these …

[HTML][HTML] Neuroprotective Properties of Bis-Sulfonamide Derivatives Against 6-OHDA-Induced Parkinson's Model via Sirtuin 1 Activity and in silico Pharmacokinetic …

S Apiraksattayakul, R Pingaew… - Frontiers in Molecular …, 2022 - frontiersin.org
Parkinson's disease (PD) is considered one of the health problems in the aging society. Due
to the limitations of currently available drugs in preventing disease progression, the …

Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP+-induced neurodegeneration

J Jouha, M Loubidi, J Bouali, S Hamri, A Hafid… - European Journal of …, 2017 - Elsevier
Neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and
Huntington's disease affect millions of people in the world. Thus several new approaches to …

Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/keap1 pathway

L Wang, X Cai, M Shi, L Xue, S Kuang, R Xu… - European journal of …, 2020 - Elsevier
Parkinson's disease (PD) is a slowly progressive and complex neurodegenerative disorder.
Up to date, there are no approved drugs that could slow or reverse the neurodegenerative …

[HTML][HTML] In silico evaluation and in vitro determination of neuroprotective and MAO-B inhibitory effects of pyrrole-based hydrazones: A therapeutic approach to …

M Kondeva-Burdina, E Mateev, B Angelov, V Tzankova… - Molecules, 2022 - mdpi.com
Parkinson's disease is a huge burden in modern medicinal practice. A serious drawback of
current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in …

[PDF][PDF] Pharmacotherapeutics and molecular docking studies of alpha-synuclein modulators as promising therapeutics for Parkinson's disease

R Ali, A Alam, SK Rajput, R Ahmad - Biocell, 2022 - cdn.techscience.cn
Parkinson's disease (PD) is an age-related neurodegenerative ailment that affects
dopamine-producing neurons in a specific area of the brain called the substantia nigra of the …

Neuroprotective effects and mechanisms of action of multifunctional agents targeting free radicals, monoamine oxidase B and cholinesterase in Parkinson's disease …

Z Liu, W Cai, M Lang, R Yan, Z Li, G Zhang… - Journal of Molecular …, 2017 - Springer
Parkinson's disease (PD) is a complex neurodegenerative disorder with multifactorial
pathologies, including progressive loss of dopaminergic (DA) neurons, oxidative stress …

Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease

Z Cao, X Fu, X Wang, T Zhang, L Zhong, Q Xia… - European Journal of …, 2023 - Elsevier
To discover novel multifunctional agents for the treatment of Parkinson's disease, a series of
2-hydroxyl-4-benzyloxybenzyl aniline derivatives was designed, synthesized and evaluated …

Neuroprotection by tetramethylpyrazine and its synthesized analogues for central nervous system diseases: A review

F Feng, DQ Xu, SJ Yue, YY Chen, YP Tang - Molecular Biology Reports, 2024 - Springer
Background Due to the global increase in aging populations and changes in modern
lifestyles, the prevalence of neurodegenerative diseases, cerebrovascular disorders …