The effects of historical fragmentation on major histocompatibility complex class II β and microsatellite variation in the Aegean island reptile, Podarcis erhardii

T Santonastaso, J Lighten… - Ecology and …, 2017 - Wiley Online Library
The major histocompatibility complex (MHC) plays a key role in disease resistance and is
the most polymorphic gene region in vertebrates. Although habitat fragmentation is …

Selection outweighs drift at a fine scale: lack of MHC differentiation within a family living lizard across geographically close but disconnected rocky outcrops

SK Pearson, CM Bull, MG Gardner - Molecular ecology, 2018 - Wiley Online Library
The highly polymorphic genes of the major histocompatibility complex (MHC) are involved in
disease resistance, mate choice and kin recognition. Therefore, they are widely used …

Selection, drift, and introgression shape MHC polymorphism in lizards

K Sagonas, A Runemark, A Antoniou, P Lymberakis… - Heredity, 2019 - nature.com
The major histocompatibility complex (MHC) has long served as a model for the evolution of
adaptive genetic diversity in wild populations. Pathogen-mediated selection is thought to be …

Widespread introgression of MHC genes in Iberian Podarcis lizards

TS Gaczorek, M Chechetkin, K Dudek… - Molecular …, 2023 - Wiley Online Library
Major histocompatibility complex (MHC) genes are crucial for the adaptive immune
response of jawed vertebrates. Their variation, reaching extreme levels, is driven mainly by …

Reduced MHC variation in a threatened tuatara species

HC Miller, KA Miller, CH Daugherty - Animal Conservation, 2008 - Wiley Online Library
The relationship between neutral and adaptive genetic diversity is important to understand
in assessing the implications of a population bottleneck. Fitness‐related genes, such as …

[HTML][HTML] Drift Rather than Selection Dominates MHC Class II Allelic Diversity Patterns at the Biogeographical Range Scale in Natterjack Toads Bufo calamita

I Zeisset, TJC Beebee - PLoS One, 2014 - journals.plos.org
Study of major histocompatibility complex (MHC) loci has gained great popularity in recent
years, partly due to their function in protecting vertebrates from infections. This is of particular …

Long‐term survival of a urodele amphibian despite depleted major histocompatibility complex variation

W Babik, M Pabijan, JW Arntzen… - Molecular …, 2009 - Wiley Online Library
Depletion of polymorphism at major histocompatibility complex (MHC) genes has been
hypothesized to limit the ability of populations to respond to emerging pathogens, thus …

Effects of fragmentation on genetic diversity in island populations of the Aegean wall lizard Podarcis erhardii (Lacertidae, Reptilia)

H Hurston, L Voith, J Bonanno, J Foufopoulos… - Molecular Phylogenetics …, 2009 - Elsevier
Landbridge islands offer unique opportunities for understanding the effects of fragmentation
history on genetic variation in island taxa. The formation of islands by rising sea levels can …

Genetic variation in the major histocompatibility complex of the European brown hare (Lepus europaeus) across distinct phylogeographic areas

EA Koutsogiannouli, KA Moutou, C Stamatis, L Walter… - Immunogenetics, 2014 - Springer
The major histocompatibility complex is one of the best studied systems in vertebrates
providing evidence for the long-term action of selection. Here, we examined the intra-and …

Genetic diversity and differentiation at MHC genes in island populations of tuatara (Sphenodon spp.)

HC Miller, F Allendorf, CH Daugherty - Molecular Ecology, 2010 - Wiley Online Library
Neutral genetic markers are commonly used to understand the effects of fragmentation and
population bottlenecks on genetic variation in threatened species. Although neutral markers …