Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: A virtual screening perspective for the treatment of obesity and diabetes

H Rasouli, SMB Hosseini-Ghazvini, H Adibi… - Food & function, 2017 - pubs.rsc.org
Recently, due to their biological properties, polyphenol-rich functional foods have been
proposed to be unique supplementary and nutraceutical treatments for diabetes mellitus …

Screening and identification of natural α-glucosidase and α-amylase inhibitors from partridge tea (Mallotus furetianus Muell-Arg) and in silico analysis

S Li, W Zhang, R Wang, C Li, X Lin, L Wang - Food chemistry, 2022 - Elsevier
Abstract Partridge leaves (Mallotus furetianus Muell-Arg.) have long been consumed as
popular folk substitute tea for treating hyperglycemia in China. In this study, the inhibiting …

Dietary polyphenols as natural inhibitors of α-amylase and α-glucosidase

I Ćorković, D Gašo-Sokač, A Pichler, J Šimunović… - Life, 2022 - mdpi.com
It is well known that carbohydrates are the main source of calories in most diets. However,
by inhibiting carbohydrases, intake of calories is reduced and weight loss is improved. α …

In silico approaches to identify polyphenol compounds as α-glucosidase and α-amylase inhibitors against type-II diabetes

J Riyaphan, DC Pham, MK Leong, CF Weng - Biomolecules, 2021 - mdpi.com
Type-II diabetes mellitus (T2DM) results from a combination of genetic and lifestyle factors,
and the prevalence of T2DM is increasing worldwide. Clinically, both α-glucosidase and α …

Screening alpha‐glucosidase and alpha‐amylase inhibitors from natural compounds by molecular docking in silico

CH Jhong, J Riyaphan, SH Lin, YC Chia, CF Weng - Biofactors, 2015 - Wiley Online Library
The alpha‐glucosidase inhibitor is a common oral anti‐diabetic drug used for controlling
carbohydrates normally converted into simple sugars and absorbed by the intestines …

Inhibition of α-amylase by polyphenolic compounds: Substrate digestion, binding interactions and nutritional intervention

L Sun, Y Wang, M Miao - Trends in Food Science & Technology, 2020 - Elsevier
Background α-Amylase is a key enzyme of starch digestion, playing an important role in
deciding glucose releasing amount. Inhibition of the enzyme activity by polyphenols is …

Evaluation of flavonoids from banana pseudostem and flower (quercetin and catechin) as potent inhibitors of α-glucosidase: An in silico perspective

SM Patil, RM Martiz, R Ramu, PS Shirahatti… - Journal of …, 2022 - Taylor & Francis
The amelioration of postprandial hyperglycemia in diabetic conditions could be
accomplished by the inhibition of α-glucosidases, a set of intestinal carbohydrate digestive …

Young apple polyphenols as natural α-glucosidase inhibitors: In vitro and in silico studies

T Gong, X Yang, F Bai, D Li, T Zhao, J Zhang, L Sun… - Bioorganic …, 2020 - Elsevier
In this study, the inhibitory activity of young apple polyphenols (YAP) on α-glucosidase was
investigated. Composition and inhibition analyses suggested that tannic acid (TA),(-) …

Natural products for glycaemic control: Polyphenols as inhibitors of alpha-amylase

L Sun, FJ Warren, MJ Gidley - Trends in Food Science & Technology, 2019 - Elsevier
Background α-Amylase plays an important role in starch digestion, the main source of
exogenous glucose in the human diet. Retarding glucose absorption through delaying …

Comparative study of dietary flavonoids with different structures as α-glucosidase inhibitors and insulin sensitizers

Y Jia, Y Ma, G Cheng, Y Zhang… - Journal of Agricultural and …, 2019 - ACS Publications
This work was designed to comparatively investigate 27 dietary flavonoids that act as α-
glucosidase inhibitors and insulin sensitizers. On the basis of the results of an in vitro …