[HTML][HTML] Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells

NI Díaz-Valdivia, CC Calderón, JE Díaz… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Expression of the scaffolding protein Caveolin-1 (CAV1) enhances migration and invasion of
metastatic cancer cells. Yet, CAV1 also functions as a tumor suppressor in early stages of …

Caveolin-1 in tumor progression: the good, the bad and the ugly

JG Goetz, P Lajoie, SM Wiseman, IR Nabi - Cancer and metastasis reviews, 2008 - Springer
Abstract Caveolin-1 (Cav1) is a multifunctional scaffolding protein with multiple binding
partners that is associated with cell surface caveolae and the regulation of lipid raft domains …

[HTML][HTML] Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis

R Ortiz, J Díaz, N Díaz, L Lobos-Gonzalez… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Caveolin-1 (CAV1) is a scaffolding protein that plays a dual role in cancer. In
advanced stages of this disease, CAV1 expression in tumor cells is associated with …

[HTML][HTML] Caveolin-1, a stress-related oncotarget, in drug resistance

Z Wang, N Wang, P Liu, F Peng, H Tang, Q Chen… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1
overexpression was frequently confirmed in advanced cancer stages and positively …

Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model

DP Singh, R Pathak, N Chintalaramulu, A Pandit… - Cancer Gene …, 2024 - nature.com
Abstract Caveolin-1 (Cav-1) is a critical lipid raft protein playing dual roles as both a tumor
suppressor and promoter. While its role in tumorigenesis, progression, and metastasis has …

Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms

F Sotgia, UE Martinez-Outschoorn… - Annual Review of …, 2012 - annualreviews.org
Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Caveolin‐1, cancer and therapy resistance

J Ketteler, D Klein - International journal of cancer, 2018 - Wiley Online Library
Resistance of solid tumors to chemo‐and radiotherapy remains a major obstacle in anti‐
cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is …

Cell intrinsic and extrinsic mechanisms of caveolin-1-enhanced metastasis

A Campos, R Burgos-Ravanal, MF González… - Biomolecules, 2019 - mdpi.com
Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review
will initially discuss earlier studies focused on the role as a tumor suppressor before …

[HTML][HTML] Caveolin-1 function at the plasma membrane and in intracellular compartments in cancer

L Simón, A Campos, L Leyton, AFG Quest - Cancer and Metastasis …, 2020 - Springer
Abstract Caveolin-1 (CAV1) is commonly considered to function as a cell surface protein, for
instance in the genesis of caveolae. Nonetheless, it is also present in many intracellular …

Restoration of caveolin‐1 expression suppresses growth, membrane‐type‐4 metalloproteinase expression and metastasis‐associated activities in colon cancer cells

L Nimri, H Barak, L Graeve… - Molecular …, 2013 - Wiley Online Library
Abstract Caveolin‐1 (cav‐1) and flotillin‐1 are two major structural proteins associated with
lipid rafts in mammalian cells. The membrane‐type matrix metalloproteinases (MT‐MMPs) …