Astaxanthin attenuates glutamate-induced apoptosis via inhibition of calcium influx and endoplasmic reticulum stress

X Lin, Y Zhao, S Li - European journal of pharmacology, 2017 - Elsevier
Astaxanthin (AST) is a carotenoid that has been shown to have neuroprotective effects. In
this study, it was found that AST significantly inhibited glutamate-induced loss of cell viability …

Astaxanthin protects PC12 cells from glutamate-induced neurotoxicity through multiple signaling pathways

Y Zhang, W Wang, C Hao, X Mao, L Zhang - Journal of Functional Foods, 2015 - Elsevier
Astaxanthin, a carotenoid extensively found in marine organisms and increasingly used as a
dietary supplement, has been reported to have neuroprotective effect. In this study, the …

Neuroprotective effect of astaxanthin against glutamate-induced cytotoxicity in HT22 cells: Involvement of the Akt/GSK-3β pathway

X Wen, A Huang, J Hu, Z Zhong, Y Liu, Z Li, X Pan… - Neuroscience, 2015 - Elsevier
Oxidative stress (OS) mediated the pathogenesis of Alzheimer's disease (AD). Astaxanthin
(ATX) has been reported to exert antioxidant activities as well as neuroprotective effects in …

Astaxanthin protection against neuronal excitotoxicity via glutamate receptor inhibition and improvement of mitochondrial function

SK Kandy, MM Nimonkar, SS Dash, B Mehta… - Marine Drugs, 2022 - mdpi.com
Excitotoxicity is known to associate with neurodegenerative diseases, such as Alzheimer's
disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease, as …

Astaxanthin protects against kainic acid-induced seizures and pathological consequences

Y Chang, CW Lu, YJ Chen, TY Lin, SK Huang… - Neurochemistry …, 2018 - Elsevier
Excitotoxic damage caused by increased glutamate levels is involved in the pathogenesis of
neurodegenerative diseases. Astaxanthin, a natural carotenoid with multiple health benefits …

[HTML][HTML] Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis

R Yamagishi, M Aihara - Molecular vision, 2014 - ncbi.nlm.nih.gov
Purpose Astaxanthin is a type of carotenoid known to have strong antioxidant effects. The
purpose of this study was to investigate whether astaxanthin confers a neuroprotective effect …

Astaxanthin modulates apoptotic molecules to induce death of skbr3 breast cancer cells

MS Kim, YT Ahn, CW Lee, H Kim, WG An - Marine Drugs, 2020 - mdpi.com
Astaxanthin (AST) is related to apoptosis but the details of the mechanism of how AST
makes apoptosis is not clear. The present study investigated apoptotic effects of AST to …

[HTML][HTML] Astaxanthin reduces demyelination and oligodendrocytes death in a rat model of multiple sclerosis

A Lotfi, M Soleimani, N Ghasemi - Cell Journal (Yakhteh), 2021 - ncbi.nlm.nih.gov
Objective Astaxanthin (AST) is a carotenoid with anti-oxidative, anti-inflammatory, and anti-
apoptotic properties. It has also been reported that AST exerts protective effects against …

[HTML][HTML] Astaxanthin protects spinal cord tissues from apoptosis after spinal cord injury in rats

S Li, X Gao, Q Zhang, X Zhang, W Lin… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background There is emerging evidence that astaxanthin plays a significant role in
protecting neuro-cells from apoptosis after central nervous system injury. Our study …

Astaxanthin reduces isoflurane-induced neuroapoptosis via the PI3K/Akt pathway

CM Wang, XL Cai, QP Wen - Molecular Medicine …, 2016 - spandidos-publications.com
Astaxanthin is an oxygen-containing derivative of carotenoids that effectively suppresses
reactive oxygen and has nutritional and medicinal value. The mechanisms underlying the …