The programmed cell death 1 (PD-1) receptor plays a major role in regulating T cell
activation. Our aim was to determine how inflammation influences PD-1-mediated T cell …

INTROduCTION Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are characterized by
chronic inflam‑matory processes mediated by proinflammatory cytokines that affect the …

Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The
programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in …

Introduction The programmed cell death 1 (PD-1) protein is a critical regulator of T-cell
activation and is also an important therapeutic target for autoimmune diseases. Little is …

The etiology of rheumatoid arthritis (RA) is thought to involve dysfunction of the programmed
cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) pathway; PD-1 negatively …

Rheumatoid arthritis (RA) is characterized by chronic inflammatory process that targets the
synovial lining of diarthrodial joints. Programmed death 1 (PD-1) plays a key role in the …

It is well known that lymphocytes are important in rheumatoid arthritis (RA). Programmed cell
death-1 (PD‑1) is one of the immunosuppressive costimulatory molecules, which mediates …

The activation of antigen specific T cells during an immune response is a tightly regulated
process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory …

Abstract Programmed death-1 (PD-1) is an inhibitory co-receptor that is highly expressed in
T lymphocytes that has been shown to downregulate inflammatory responses in several …

Objective Arthritis associated with immune checkpoint inhibitor therapies highlights the
importance of immune checkpoint expression for joint homeostasis. We investigated the role …