The goal of this review is to describe in what ways feedback or adaptive stimulation may be
delivered and adjusted based on relevant biomarkers. Specific treatment mechanisms …

The development of closed-loop deep brain stimulation (DBS) systems represents a
significant opportunity for innovation in the clinical application of neurostimulation therapies …

While modulating neural activity through stimulation is an effective treatment for neurological
diseases such as Parkinson's disease and essential tremor, an opportunity for improving …

Sensing enabled implantable devices and next-generation neurotechnology allow real-time
adjustments of invasive neuromodulation. The identification of symptom and disease …

Over the past three decades, deep brain stimulation (DBS) for Parkinson's disease (PD) has
been applied in a continuous open loop fashion, unresponsive to changes in a given …

Introduction: Epilepsy affects more than 1% of the US population, and over 30% of adults
with epilepsy do not respond to antiseizure medications without life-impacting medication …

Neurostimulation as a therapeutic tool has been developed and used for a range of different
diseases such as Parkinson's disease, epilepsy, and migraine. However, it is not known why …

Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

The identification of oscillatory neural markers of Parkinson's disease (PD) can contribute
not only to the understanding of functional mechanisms of the disorder, but may also serve …

Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …