Cancer stem cells (CSC) are associated with tumor resistance and are characterized in
gastric cancer (GC). Studies have indicated that Notch and wnt-beta-catenin pathways are …

It has been proposed that the Notch signaling pathway may serve a pivotal role in cellular
differentiation, proliferation and apoptosis. However, the function of Notch signaling in …

γ-secretase inhibitors (GSIs), the indirect inhibitors of Notch, are emerging as a new class of
anticancer agents for the treatment of solid and hematological malignancies, but little is …

The Wnt1 protein, a secreted ligand that activates Wnt signaling pathways, contributes to the
self-renewal of cancer stem cells (CSCs) and thus may be a major determinant of tumor …

Current medication for gastric cancer patients has a low success rate and the patients
develop rapid tolerance to these drugs. Therefore, the development of new regimens is …

Cancer stem cells (CSCs) have been defined as a unique subpopulation in tumors that
possess the ability to initiate tumor growth and sustain tumor self-renewal. Although the …

The existence of gastric cancer stem cells (CSCs) has not been definitively proven and
specific cell surface markers for identifying gastric CSCs have largely not been identified …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high rate of
metastasis. Recent studies have indicated that the Notch signalling pathway is important in …

Drug resistance in gastric cancer largely results from the gastric cancer stem cells (GCSCs),
which could be targeted to improve the efficacy of chemotherapy. In this study, we identified …

In recent decades, the study of the mechanism of tumorigenesis has brought much progress
to cancer treatment. However, cancer stem cell (CSC) theory has changed previous views of …