The complex microenvironment that surrounds hematopoietic stem cells (HSCs) in the bone
marrow niche involves different coordinated signaling pathways. The stem cells establish …

Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of
glycoproteins with exquisite structural complexity. They are ubiquitously expressed across …

This review summarizes our current understanding of the presence and function of heparan
sulfate proteoglycans (HSPGs) in skeletal development and hematopoiesis. Although …

Heparan sulfate proteoglycans (HSPG s) have essential functions during embryonic
development and throughout postnatal life. To exert these functions, they undergo a series …

Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

The aim of this review is to explore the idea that the glycosaminoglycan sugar heparan
sulfate (HS), richly concentrated on the plasma membrane of all animal cells studied so far …

Nearly all vertebrate cells have been shown to express heparan sulfate proteoglycans
(HSPGs) at the cell surface. The HSPGs bind to many secreted signaling proteins, including …

Stem cell localization, conservation, and differentiation is believed to occur in niches in the
marrow stromal microenvironment. Our recent observation that long-term in vitro human …

Heparan sulfate (HS) is a component of cell surface and matrix-associated proteoglycans
(HSPGs) that, collectively, play crucial roles in many physiologic processes including cell …

Heparan sulfate proteoglycans are complex molecules composed of a core protein with
covalently attached glycosaminoglycan chains. While the protein part determines …