Heart failure is a global public health problem that affects more than 26 million people
worldwide. The global burden of heart failure is growing and is expected to increase …

Background: Epidemiology of patients with worsening heart failure and reduced ejection
fraction (HFrEF) in the real-world setting is not well described. Objectives: The purpose of …

Importance Worldwide, the burden of heart failure has increased to an estimated 23 million
people, and approximately 50% of cases are HF with reduced ejection fraction (HFrEF) …

Among patients with heart failure with reduced ejection fraction, investigators have
repeatedly identified a subgroup whose left ventricular ejection fraction and structural …

By definition, patients with heart failure and preserved ejection fraction are characterized by
a normal or near-normal left ventricular ejection fraction, but marked heterogeneity in the …

Approximately half of the patients with signs and symptoms of heart failure have a left
ventricular ejection fraction that is not markedly abnormal. Despite the historically initial …

The number of persons with heart failure has continued to rise over the last several years.
Approximately one-half of those living with heart failure have heart failure with preserved …

Understanding of contemporary pharmacological therapy for chronic heart failure continues
to evolve. In this Review, we discuss how findings from clinical trials have caused the roles …

Heart failure patients are classified by ejection fraction (EF) into distinct groups: heart failure
with preserved ejection fraction (HFpEF) or heart failure with reduced ejection fraction …

The clinical syndrome comprising heart failure (HF) symptoms but with a left ventricular
ejection fraction (EF) that is not diminished, eg, HF with preserved EF, is increasingly the …