Identification of protein complexes by using a spatial and temporal active protein interaction network

M Li, X Meng, R Zheng, FX Wu, Y Li… - … /ACM transactions on …, 2017 - ieeexplore.ieee.org
The rapid development of proteomics and high-throughput technologies has produced a
large amount of Protein-Protein Interaction (PPI) data, which makes it possible for …

Mining temporal protein complex based on the dynamic pin weighted with connected affinity and gene co-expression

X Shen, L Yi, X Jiang, T He, X Hu, J Yang - PloS one, 2016 - journals.plos.org
The identification of temporal protein complexes would make great contribution to our
knowledge of the dynamic organization characteristics in protein interaction networks (PINs) …

Construction and application of dynamic protein interaction network based on time course gene expression data

J Wang, X Peng, M Li, Y Pan - Proteomics, 2013 - Wiley Online Library
In recent years, researchers have tried to inject dynamic information into static protein
interaction networks (PIN s). The paper first proposes a three‐sigma method to identify …

Detecting protein complexes from active protein interaction networks constructed with dynamic gene expression profiles

Q Xiao, J Wang, X Peng, FX Wu - Proteome science, 2013 - Springer
Abstract Background Protein interaction networks (PINs) are known to be useful to detect
protein complexes. However, most available PINs are static, which cannot reflect the …

Construction of dynamic probabilistic protein interaction networks for protein complex identification

Y Zhang, H Lin, Z Yang, J Wang - BMC bioinformatics, 2016 - Springer
Background Recently, high-throughput experimental techniques have generated a large
amount of protein-protein interaction (PPI) data which can construct large complex PPI …

A Novel Core‐Attachment–Based Method to Identify Dynamic Protein Complexes Based on Gene Expression Profiles and PPI Networks

Q Xiao, P Luo, M Li, J Wang, FX Wu - Proteomics, 2019 - Wiley Online Library
Cellular functions are always performed by protein complexes. At present, many approaches
have been proposed to identify protein complexes from protein–protein interaction (PPI) …

Identifying dynamic protein complexes based on gene expression profiles and PPI networks

M Li, W Chen, J Wang, FX Wu… - BioMed research …, 2014 - Wiley Online Library
Identification of protein complexes from protein‐protein interaction networks has become a
key problem for understanding cellular life in postgenomic era. Many computational …

Dynamic protein interaction network construction and applications

J Wang, X Peng, W Peng, FX Wu - Proteomics, 2014 - Wiley Online Library
With more dynamic information available, researchers' attention has recently shifted from
static properties to dynamic properties of protein–protein interaction networks. To …

A method for predicting protein complex in dynamic PPI networks

Y Zhang, H Lin, Z Yang, J Wang, Y Liu, S Sang - BMC bioinformatics, 2016 - Springer
Background Accurate determination of protein complexes has become a key task of system
biology for revealing cellular organization and function. Up to now, the protein complex …

PCD-GED: Protein complex detection considering PPI dynamics based on time series gene expression data

A Lakizadeh, S Jalili, SA Marashi - Journal of theoretical biology, 2015 - Elsevier
Detection of protein complexes from protein–protein interaction (PPI) networks is essential to
understand the function of cell machinery. However, available PPIs are static, and cannot …