The possibility that hypothermia might prevent or lessen asphyxial brain injury is a “dream
revisited”, first proposed more than 300 years ago by Floyer [1]. Early experimental studies …

Perinatal asphyxia may occur in utero, during labor and delivery, or in the postnatal period.
There are numerous causes, and the clinical manifestations vary. Infants who experience …

Background: Perinatal asphyxia remains one of the most devastating neurologic processes.
There is experimental and clinical evidence that cerebral cooling may suppress the …

Experimental studies show that, following hypoxic ischaemic injury, mild induced
hypothermia—a reduction of body temperature by about 3° C—preserves cerebral energy …

The possibility that hypothermia has a therapeutic role during or after resuscitation from
severe perinatal asphyxia has been a longstanding focus of research. Early studies using …

Therapeutic hypothermia is the only treatment currently recommended for moderate or
severe encephalopathy of hypoxic‒ischaemic origin in term neonates. Though the effects of …

Many years of experimental work on hypoxic-ischaemic injury have supported the
hypothesis that cooling the body and brain after the primary injury offers permanent …

Modest Hypothermia as a Neuroprotective Strategy in High-Risk Term Infants - Clinics in
Perinatology Skip to Main Content Advertisement Clinics in Perinatology Log in Register Log …

Although hypoxic-ischemic encephalopathy (HIE) is relatively rare, it commonly results in
devastating long-term mortality and death. Intervention against this condition has been …

To cool or not to cool newborn infants with neonatal encephalopathy following birth
asphyxia is one of today's hottest questions in neonatal medicine, close to 50 years since …