Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

The classical view of B cells in the biology of autoimmune responses to infectious and self-
antigens (Ag) that they promote immunity primarily by producing antibodies (Ab) is far from …

The pathogenic roles of B cells in autoimmune diseases occur through several mechanistic
pathways that include autoantibodies, immune complexes, dendritic and T cell activation …

B cells are essential for the development and pathogenesis of both systemic and organ-
specific autoimmune diseases. Autoreactive B cells are typically thought of as sources of …

B cells play a variety of immunoregulatory roles through their antigen-presentation ability
and through cytokine and chemokine production. Innate immune activation of B cells may …

The pathogenic roles of B cells in human autoimmune diseases involve a multitude of
mechanistic pathways and include the well-established contributions of autoantibodies and …

B cells are critical players in the orchestration of properly regulated immune responses,
providing protection against infectious agents without inflicting autoinflammatory damage. A …

In this review, we describe the non‐antibody‐mediated functions of B cells within the
immune system. In addition to antibody production, B cells also present antigen to T cells …

In the past two decades it has become clear that in addition to antigen presentation and
antibody production B cells play prominent roles in immune regulation. While B cell-derived …

Autoimmunity results from abnormal B‐and T‐cell recognition of self‐antigens, which leads
to autoantibody production in many cases. Autoantibodies produced by B‐cell‐derived …