Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrent
UTIs becoming increasingly frequent owing to the emergence of antibiotic-resistant bacterial …

Inflammasomes are supramolecular structures that sense molecular patterns from
pathogenic organisms or damaged cells and trigger an innate immune response, most …

Irritative voiding symptoms (eg increased frequency and urgency) occur in many common
pathologic conditions such as urinary tract infections and bladder outlet obstruction, and …

Uropathogenic Escherichia coli (UPEC) is the main etiological agent of urinary tract
infections (UTIs). Little is known about interactions between UPEC and the inflammasome, a …

Background: The inflammasome is a complex of proteins in the cytoplasm that consists of
three main components: a sensor protein (receptor), an adapter protein and caspase-1 …

Abstract The NLRP3 inflammasome, IL-1β release and pyroptosis (cell lysis) have recently
been proposed to be essential for the progression of urinary tract infection (UTI) and …

The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine
production in response to infection and tissue injury. Pattern recognition receptors that are …

The immune system has a central role in eliminating detrimental factors, by frequently
launching inflammatory responses towards pathogen infection and inner danger signal …

Bladder inflammation (cystitis) underlies numerous bladder pathologies and is elicited by a
plethora of agents such as urinary tract infections, bladder outlet obstruction …

The inflammasome-associated proteins caspase-1, caspase-4 and NLRP3 have been
emphasised to be essential in the host cell response during urinary tract infection (UTI) by …