Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

A growing body of evidence indicates that, over the course of evolution of the immune
system, arginine has been selected as a node for the regulation of immune responses. An …

Macrophages play a major role in the immune system, both as antimicrobial effector cells
and as immunoregulatory cells, which induce, suppress or modulate adaptive immune …

The activation of macrophages through Toll-like receptor (TLR) signaling pathways is a
major component of innate immune responses to infection. Because the production of nitric …

Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Macrophages are involved in inflammation from induction to resolution. Polarization of
macrophages along the M1 (classical) or M2 (alternative) axis occurs during inflammation …

The metabolism of the amino acid l-arginine is emerging as a crucial mechanism for the
regulation of immune responses. Here, we characterized the impact of l-arginine deprivation …

A heterogeneous set of cells that are commonly grouped as “myeloid cells”, interacts in a
complex landscape of physiological and pathological situations. In this review we attempt to …

Abstract l-Arginine is an essential amino acid for birds and young mammals, and it is a
conditionally essential amino acid for adult mammals, as it is important in situations in which …

The balance of arginine metabolism via nitric oxide synthase (NOS) or arginase is an
important determinant of the inflammatory response of murine macrophages and dendritic …