[HTML][HTML] Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance
Abstract γδ T cells are considered to be innate-like lymphocytes that respond rapidly to
stress without clonal selection and differentiation. Here we use next-generation sequencing …
stress without clonal selection and differentiation. Here we use next-generation sequencing …
[HTML][HTML] Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program
JL McMurray, A von Borstel, TE Taher, E Syrimi… - Cell reports, 2022 - cell.com
Summary γδ T cells are generally considered innate-like lymphocytes, however, an"
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …
adaptive-like" γδ compartment has now emerged. To understand transcriptional regulation …
[HTML][HTML] The human Vδ2+ T-cell compartment comprises distinct innate-like Vγ9+ and adaptive Vγ9- subsets
Vδ2+ T cells form the predominant human γδ T-cell population in peripheral blood and
mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we …
mediate T-cell receptor (TCR)-dependent anti-microbial and anti-tumour immunity. Here we …
[HTML][HTML] Innate immune functions of human γδ T cells
S Beetz, D Wesch, L Marischen, S Welte, HH Oberg… - Immunobiology, 2008 - Elsevier
γδ T cells expressing the Vγ9Vδ2 T cell receptor (TCR) account for 1–10% of CD3+
peripheral blood T lymphocytes. Vγ9Vδ2 T cells use their TCR as a pattern recognition …
peripheral blood T lymphocytes. Vγ9Vδ2 T cells use their TCR as a pattern recognition …
[HTML][HTML] Recasting human Vδ1 lymphocytes in an adaptive role
γδ T cells are unconventional lymphocytes commonly described as 'innate-like'in function,
which can respond in both a T cell receptor (TCR)-independent and also major …
which can respond in both a T cell receptor (TCR)-independent and also major …
Innate and adaptive γδ T cells: How, when, and why
M Papadopoulou, G Sanchez Sanchez… - Immunological …, 2020 - Wiley Online Library
Summary γδ T cells comprise the third cell lineage of lymphocytes that use, like αβ T cells
and B cells, V (D) J gene rearrangement with the potential to generate a highly diverse T cell …
and B cells, V (D) J gene rearrangement with the potential to generate a highly diverse T cell …
γδ T cell update: adaptate orchestrators of immune surveillance
AC Hayday - The Journal of Immunology, 2019 - journals.aai.org
As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
During ontogeny, γδ T cells emerge from the thymus and directly seed peripheral tissues for
in situ immunity. However, their functional role in humans has largely been defined from …
in situ immunity. However, their functional role in humans has largely been defined from …
Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation
CL Roark, MK Aydintug, J Lewis, X Yin… - Journal of Leucocyte …, 2004 - academic.oup.com
The Vγ6/Vδ1+ cells, the second murine γδ T cell subset to arise in the thymus, express a
nearly invariant T cell receptor (TCR), colonize select tissues, and expand preferentially in …
nearly invariant T cell receptor (TCR), colonize select tissues, and expand preferentially in …
[HTML][HTML] Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire
Vγ9Vδ2+ lymphocytes are among the first T-cells to develop in the human fetus and are the
predominant peripheral blood γδ T-cell population in most adults. Capable of broad …
predominant peripheral blood γδ T-cell population in most adults. Capable of broad …