Evolution of bacterial virulence

M Diard, WD Hardt - FEMS microbiology reviews, 2017 - academic.oup.com
Bacterial virulence is highly dynamic and context-dependent. For this reason, it is
challenging to predict how molecular changes affect the growth of a pathogen in a host and …

Common themes in microbial pathogenicity

BB Finlay, S Falkow - Microbiological reviews, 1989 - Am Soc Microbiol
A bacterial pathogen is a highly adapted microorganism which has the capacity to cause
disease. The mechanisms used by pathogenic bacteria to cause infection and disease …

Dissecting the biology of a pathogen during infection

DM Heithoff, CP Conner, MJ Mahan - Trends in microbiology, 1997 - cell.com
o expres expression studies reveal many bacterial genes that contribute to the fitness of the
organism in the context of host ecology. This collection of virulence genes defines the …

Common themes in microbial pathogenicity revisited

BB Finlay, S Falkow - Microbiology and molecular biology reviews, 1997 - Am Soc Microbiol
Bacterial pathogens employ a number of genetic strategies to cause infection and,
occasionally, disease in their hosts. Many of these virulence factors and their regulatory …

Virulence evolution and the trade‐off hypothesis: history, current state of affairs and the future

S Alizon, A Hurford, N Mideo… - Journal of evolutionary …, 2009 - academic.oup.com
It has been more than two decades since the formulation of the so‐called 'trade‐
off'hypothesis as an alternative to the then commonly accepted idea that parasites should …

Virulence and transmissibility of pathogens: what is the relationship?

M Lipsitch, ER Moxon - Trends in microbiology, 1997 - cell.com
The fitness of most pathogenic microorganisms depends on transmission from host to host.
This requires adaptation for dissemination, translocation and survival between hosts, as well …

[HTML][HTML] From gene to protein—How bacterial virulence factors manipulate host gene expression during infection

L Denzer, H Schroten, C Schwerk - International Journal of Molecular …, 2020 - mdpi.com
Bacteria evolved many strategies to survive and persist within host cells. Secretion of
bacterial effectors enables bacteria not only to enter the host cell but also to manipulate host …

Bacterial virulence: can we draw the line?

TM Wassenaar, W Gaastra - FEMS microbiology letters, 2001 - academic.oup.com
The molecular approach to microbial pathogenesis has resulted in an impressive amount of
data on bacterial virulence genes. Bacterial genome sequences rapidly add candidate …

Evolution of virulence

PW Ewald - Infectious Disease Clinics, 2004 - id.theclinics.com
Human history cannot be understood well without understanding the causes and
consequences of human disease. This fact has become amply apparent over the past few …

Molecular mechanisms of pathogenicity: how do pathogenic microorganisms develop cross-kingdom host jumps?

P Van Baarlen, A Van Belkum… - FEMS microbiology …, 2007 - academic.oup.com
It is common knowledge that pathogenic viruses can change hosts, with avian influenza, the
HIV, and the causal agent of variant Creutzfeldt–Jacob encephalitis as well-known …