Parkinson's disease (PD) is histologically characterized by the accumulation of α-synuclein
particles, known as Lewy bodies. The second most common neurodegenerative disorder …

Parkinson's disease (PD) is most frequently associated with characteristic motor symptoms
that are known to arise with degeneration of dopaminergic neurons. However, patients with …

The nonmotor features of Parkinson's disease: pathophysiolog... : Current Opinion in
Neurology The nonmotor features of Parkinson's disease: pathophysiology and …

Parkinson's disease (PD) is a multisystem alpha-synucleinopathic neurodegenerative
disease and the most prevalent neurodegenerative disorder after Alzheimer's disease with a …

The basal ganglia circuitry processes the signals that flow from the cortex, allowing the
correct execution of voluntary movements. In Parkinson's disease, the degeneration of …

The excitatory corticostriatal pathway, which plays a critical role in the building up and
storage of adaptive motor behaviours, can undergo long-lasting, activity-dependent changes …

Parkinson's disease (PD) symptoms originate from the loss of the dopaminergic control of
neuronal activity in the striatum. Permanent loss of dopaminergic terminals in the striatum …

Parkinson's disease is a neurodegenerative disease with motor and non-motor symptoms. In
Parkinson's disease, a neurotransmitter imbalance occurs in the extrapyramidal system with …

Parkinson's disease (PD) is the second most common multifactorial neurodegenerative
disorder affecting 3% of population during elder age. The loss of substantia nigra, pars …

The importance of the striatal dopamine (DA) deficiency and the DA substituting property of
levodopa for the pathophysiology and therapy of Parkinson's disease (PD) is reiterated. In …