Pathways underlying mouse embryonic development have always informed efforts to derive,
maintain, and drive differentiation of human pluripotent stem cells. However, direct …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

It is widely anticipated that human embryonic stem (ES) cells will serve as an experimental
model for studying early development in our species, and, conversely, that studies of …

Pluripotency defines the propensity of a cell to differentiate into, and generate, all somatic,
as well as germ cells. The epiblast of the early mammalian embryo is the founder population …

In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture
equivalent of the late epiblast in the pre-implantation embryo, with which they share a …

Naïve pluripotent mouse embryonic stem cells (ESCs) resemble the preimplantation epiblast
and efficiently contribute to chimaeras. Primate ESCs correspond to the postimplantation …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …

Pluripotent stem cells have broad utility in biomedical research and their molecular
regulation has thus garnered substantial interest. While the principles that establish and …

Developmental biology has long benefited from studies of classic model organisms.
Recently, human pluripotent stem cells (hPSCs), including human embryonic stem cells and …

Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to
differentiate into any cell type derived from the three germ layers of ectoderm (epidermal …